The only railroad serving the area is the St. Louis and San Francisco Railway, popularly known as the Frisco. Its main line, which roughly parallels the earlier tracks of the Missouri Pacific, was built through the area about 1886-87. A station was maintained for many years at the railroad's crossing at Clifton Avenue. According to the Frisco Railway's timetable for 1903, ten commuter trains, five in each direction, were operated daily from Monday through Friday. There were twelve trains on Saturday and only six on Sunday. Records of 1924 indicate that the service was abandoned by that time.
Transit service to the Clifton area was provided solely by the Tower Grove Street Car Line for many years. Originally a horse car line terminating at Arsenal Street and Grand Avenue, it was electrified and extended out Arsenal as far as Kingshighway in the 1890's. After the consolidation of the street car lines into a city-wide transit system in 1900, the line was further extended on Arsenal Street and Southwest Avenue to a loop at Columbia and Tamm Avenues. The street cars were superseded by buses during the 1950's and in recent years this line's service has been lengthened to reach Maplewood over Southwest Avenue. About 1924, bus service was begun by the Peoples Motorbus Company's Lindenwood Line, with doubledeck buses operating directly to downtown. This line began at Fyler Avenue Bridge and traversed the district on Fyler, Ivanhoe and Scanlan Avenues to Watson Road and thence eastwardly on Southwest and Vandeventer Avenues.
Bus service on Hampton Avenue was begun on April 1, 1940, running from the Southampton street car loop west to Hampton, and thence northwardly to Oakland Avenue. In July, 1940, the service was extended to the Cherokee loop on Gravois Avenue. In 1945, the line began operations across Forest Park to Delmat and DeBaliviere and in 1964 it was combined with the Goodfellow line and was extended to Baden.