Monkeypox Information

Information about the monkeypox virus in the City of St. Louis


Monkeypox is a disease caused by infection with the monkeypox virus. Monkeypox virus is part of the same family of viruses as variola virus, the virus that causes smallpox. Monkeypox symptoms are similar to smallpox symptoms but milder, and monkeypox is rarely fatal. Monkeypox is not related to chickenpox.

As of now, there is no treatment for monkeypox. However, antiviral medication for smallpox may be used for people who are likely to get severely ill.

View information from the CDC about monkeypox.
View information from the World Health Organization about monkeypox.


St. Louis Case Count

City of St. Louis Data as of
September 30, 2022

Number of confirmed monkeypox cases in the City of St. Louis 26 Confirmed case is defined as: lab evidence of virus DNA by PCR or Next-Generation sequencing, OR isolation of virus in culture from clinical specimen.
Number of probable monkeypox cases 22 Probable cases indicate detection of Orthopoxvirus DNA by polymerase chain reaction or immunohistochemical or electron microscopy testing methods.

U.S. Case Map as of September 29, 2022

Weekly Data Reports

Monkeypox Update - September 12, 2022
Monkeypox Update - September 6, 2022
Monkeypox Update - August 29, 2022
Monkeypox Update - August 23, 2022
Monkeypox Update - August 16, 2022

Education Toolkit

Educational materials produced to share accurate information about monkeypox

Monkeypox Education

Vaccine Information

Due to the low supply of vaccine currently available, monkeypox vaccination is being recommended for a very limited number of people since the virus is not spreading widely in the St. Louis area. 

The Department of Health (DOH) is vaccinating people who are likely to have been recently exposed to monkeypox. DOH typically reaches out to eligible individuals as part of the process of working with people who already have monkeypox (case investigation). If you believe you have had close exposure to someone with monkeypox and have not been contacted by DOH, please email our Communicable Disease section or call (314) 657-1499. Please include the details of your exposure (or potential exposure), including dates and types of contact. If you meet the criteria, we will contact you to make a vaccine appointment.

Anyone can get monkeypox because it is transmitted through close, skin-to-skin contact. At present, because of the sustained close contact experienced during sex, it is disproportionately affecting gay, bisexual, and other men who have sex with men (including transgender and non-binary men). For this reason, we ask that if you are in this category, please complete the Monkeypox vaccine screening form and we will reach out to you via email or text. Please note that vaccine demand far exceeds supply, and we may not reach out to you immediately. There is no need to fill out the form more than once. 

Please note that you cannot get vaccinated if it has been more than 14 days since you were exposed. You also cannot get vaccinated if you already have symptoms of monkeypox.

Additional information on the Monkeypox Vaccine availability in the St. Louis region


Monkeypox symptoms usually appear one to two weeks after infection, but sometimes this can extend to three weeks. You may experience the symptoms listed below:

  • Fever
  • Chills
  • Rashes
  • Muscle pain/Backaches
  • Fatigue/Exhaustion
  • Swollen lymph nodes behind ears, on the neck, in the groin area, or in the armpits

Anyone can get monkeypox if they come into close contact with an infected person. In the 2022 outbreak, the largest number of cases have been documented in sexual networks among men who have sex with men. 

The community should take precautions and limit skin-to-skin contact or intimate contact with anybody who has monkeypox. 

Spread and Prevention

Monkeypox is spread through:

  • direct contact with an infectious rash, scabs, or body fluids
  • respiratory secretions during prolonged, face-to-face contact, such as kissing, cuddling, or sex
  • touching objects, fabrics (such as clothing or linens) that previously touched the rash or body fluids of someone with monkeypox
  • being scratched or bitten by an animal infected with monkeypox

Monkeypox can spread from the time symptoms start until the rash has fully healed and a fresh layer of skin has formed. This can take several weeks.

To prevent contracting monkeypox, you should avoid:

  • Skin-to-skin physical contact and intimate contact with a person with monkeypox
  • Do not handle, touch, or share utensils, cups, bedding, towels, or clothing of a person diagnosed with monkeypox
  • Frequent wash hands with soap and water or use an alcohol-based sanitizer




Department of Health

(314) 612-5100

1520 Market, Room 4051
St. Louis, MO 63103

Monday - Friday 8:00am - 5:00pm

Contact the Department of Health

Was this page helpful?      

Comments are helpful!
500 character limit

Feedback is anonymous.

1 comment from someone like you has helped us improve this page. Keep the feedback coming!