College Hill general boundaries are defined as Adelaide Ave. on the North, southward to Interstate Highway 70 (I-70), on the East, westward to Ferry St on the South, northward to N. Florissant Ave. to W. Florissant Ave. on the West to Adelaide Ave.
Before residential development in College Hill began, the area was rural in character and consisted of several large farm estates. The prominent landowners were John O’Fallon, Dr. John Gano Gryan, Edward Hempstead, and Lewis Bissell. The largest landowner in the area was O’Fallon. Much of his 600-acre estate became what are today O’Fallon Park and College Hill.