Columbus Square general boundaries are defined as Cass Ave. on the North, southward to Interstate Highway 70 (I-70), on the East, westward to Cole St. on the South, northward to N. Tucker Blvd to N. 13th St. on the West to Cass Ave.
Before residential development in College Hill began, the area was rural in character and consisted of several large farm estates. The prominent landowners were John O’Fallon, Dr. John Gano Gryan, Edward Hempstead, and Lewis Bissell. The largest landowner in the area was O’Fallon. Much of his 600-acre estate became what are today O’Fallon Park and College Hill.